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Pragmatic trials are studies designed to inform real-world clinical practice. They are typically described as a focus on the practical aspects of design that include recruitment and consent, adherence and 무료 프라그마틱 the use of routinely available equipment.
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A pragmatic trial that uses a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is essential for pragmatic trials to be able to prove their validity and reduces bias in the results. A high degree of heterogeneity, however, can cause problems with the trial design.
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Pragmatic trials seek to replicate real-life settings and achieve maximum external validity. Usually, they are requested by practitioners and policymakers to inform their decisions. They can also be used to assess the cause-effect relationship of an intervention and its effects. However, they shouldn't be used to substitute for explanatory studies.
The idea of pragmatism is controversial and there are concerns about whether pragmatic trials should replace explanatory tests or if they should be an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which prove a physiological or clinical hypothesis as well as pragmatic trials, which guide the policy and practice of. They also proposed the framework for pragmatic trials, dubbed PRECIS.2 This tool was designed to define the characteristics of a pragmatic trial which includes recruitment, design and delivery of the intervention, as well as follow-up.
There is a growing trend in the number of pragmatic trials that have been published. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming more sensitive to the subject of pragmatics. It is important to remember that the majority were conducted in primary care settings.
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