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The BIOFIRE System and Your Immune System

The BIOFIRE System offers syndromic testing for infectious diseases, allowing healthcare professionals to choose the appropriate test the first time. Patients benefit from faster diagnosis and more specific treatment. Clinicians benefit from better stewardship of antibiotics. Labs gain efficiency and cost savings.

The BioFire FilmArray Pneumonia plus panel (PN panel) analyzes native sputum endotracheal aspirate, and bronchoalveolar specimens (including mini-BAL) for 33 clinically relevant pathogens and antimicrobial resistance genes, with semiquantitative results within an hour.

Respiratory

The burning of biomass, like wood, plants and other organic materials, creates gaseous pollution and fine particles that adversely affect the respiratory system. Additionally, the environmental issues caused by forest fires such as droughts, can be potentiated by climate change, increasing the negative effects on the human health.

In the United States wildfire smoke is associated with hospitalizations caused by respiratory diseases such as asthma, COPD, and lung cancer. Additionally, this kind of air pollution is an important risk factor for cardiovascular diseases and is a significant contributor to the burden of disease for the most vulnerable population that include those who are of lower socioeconomic status (SES).

In the COVID-19 pandemic, a number of communities were exposed to harmful levels of air pollution resulting from wildfires. The response to public health has been limited to a communication campaign regarding managing symptoms. This gap in knowledge is troubling considering the evidence of potential health risks from continued exposure to smoke and other causes of poor air quality.

Researchers are currently evaluating the best methods to safeguard the public's health in future events of this type. NIH is funding research on this important public health issue through the BLUE CORAL study as well as its successor, FIRE CORAL.

For the first time that a prospective study is conducted, it will examine the long-term effects of exposure to smoke from wildfires or other sources. FIRE CORAL is looking for adult participants who are hospitalized for bio Fire the COVID-19 index episode who have a fluency in English or Spanish and are not pregnant. The Fire Coral protocol includes a variety of assessments in person that objectively measure the pulmonary function testing, lung imaging and functional assessment.

The lungs are the most sensitive to the effects of smoke and other particles because they can trigger or exacerbate chronic respiratory diseases, such as emphysema and COPD and increase the risk of pneumonia. Smoke exposure can have adverse effects on health. To lessen or stop these effects, you should avoid outdoor activities and wear the EPA "N95" mask. The mask is designed to trap fine particles.

Smoking cigarettes can cause irritation to the eyes, throat and nose. To lessen the effects the lungs must be flushed with plenty of water and taking medicines that decrease inflammation, like corticosteroids.

Bloodstream

Your bloodstream is on the front lines of fighting germs that invade your body. Special cells called dendritic cells are akin to your fire department's call center; they take antigens (molecules that trigger an immune response) from invading germs and bio ethanal fire then release proteins that alert other white blood cells to come to fight them. The total white blood cells, differentials and band cells grew after firefighters' firefighting tasks, compared to levels after vigorous exercise that did not include firefighting.

Skin

As the wildfires in California released smoke and dust into the air this past autumn and winter dermatologists were concerned about how that might affect the skin of those who were exposed to it. Maria Wei, a graduate student at the University of California, Irvine, is studying how extreme pollution from wildfires affects the skin. Her research was published on April 22, 2012 in Scientific Reports.

Wei's study shows that the temperature of the skin fluctuates depending on the length of time the body is exposed. It can take as long as two hours for a skin to reach its flash point -- the place where it begins to burn and then turns into a ashy. This is why it's crucial to avoid being near a bio-ethanol fire or campfire, and why you should wear protective clothing if you are outdoors in the midst of a forest fire or even on the heat of the day.

Forest fires will continue to happen, despite the precautions taken to stop fires from causing pollution. Wei predicts that as climate change causes forests to burn faster, the number of people suffering from wildfires will grow. That means more people will have to wear long sleeves, hats and thick moisturizers.

It's also important to know that atopic dermatitis (itchy skin) that many people suffer from can be exacerbated by the air pollution from wildfires. She claims that the particles in smoke can clog pores which can cause skin irritation.

Another issue is that atopic dermatitis is known to make people more sensitive to UV light, which can be aggravated by smoke from wildfires. This could lead to people seeking out tanning salons and apply a tan with less protection.

While a ice and fire facial may help reduce the effects of atopic skin dermatitis, it is not safe for those with an open wound or a rash on their face. This treatment is not recommended for people with active acne, or if you're pregnant or nursing. The IS Clinical Fire & Ice Facial at Novuskin, Las Vegas' premiere membership MedSpa, is an intensive, results-driven facial that bridges the gap between a mild facial and a peel without having to wait for any downtime. It's designed to rejuvenate skin, improve rosacea, decrease fine lines and acne scarring and stimulate cellular renewal. This is a great way to provide your skin with a radiant glow.

Infections

The human body is made up of a complex system of organs and tissue that work together in order to protect us against infection. Infections can be caused by microorganisms such as parasites, viruses and bacteria which infect healthy cells and cause them to multiply in uncontrolled ways. Your immune system can react by displaying signs of illness. These symptoms can range from a runny nose to an upset stomach and can also include a fever, swollen lymph glands, or an itchy scratch. The type of infection and its location can affect your symptoms.

Infections spread in many ways, but the most common are transmitted from person to person via droplets that remain in the air after coughing or sneezing. Bacterial diseases like tuberculosis, strep throat, meningococcal disease and Legionnaires' disease are spread this way, along with some viral infections like the common cold and influenza. Some infections caused by bacteria, such as skin infections and sexually transmitted diseases (STIs) like gonorrhea and chlamydia are transmitted by direct contact with infected tissue or mucous membranes as well as indirect contact with surfaces that are contaminated. Certain bacterial infections are transmitted by insects such as ticks, fleas or mosquitoes.

Some parasites and viruses are small enough to get into your bloodstream and infect your cells, which leads to serious illnesses like the common cold and Bioethanol Fire AIDS. Fungi can cause a variety of skin ailments such as ringworm, athlete's foot, biofuel fireplace insert while some are a threat to the lungs and nervous system, such as the rabies virus.

The BioFire Panel employs our revolutionary FilmArray Technology to test sputum and bronchoalveolar fluid samples to provide a complete list of pathogens involved in upper respiratory infection. The kit includes a reagent bag that includes all the chemistry required to perform reverse transcription as well as nested multiplex PCR detection in one machine. It's a simple-to-use tool to help clinicians syndromicly identify and treat patients with different respiratory symptoms. This test has been given an Emergency Use Authorization. It's available in bioMerieux CLIA medium and high complexity laboratories.